• Kenji Tomida, Nagahide Takahashi, Shinichi Saito, Nobuhisa Maeno, Kunihiro Iwamoto, Keizo Yoshida, Hiroyuki Kimura, Tetsuya Iidaka, and Norio Ozaki.
• Department of Psychiatry, Nagoya University, Graduate School of Medicine, Aichi, Japan. omh-psy@omh.ogaki.gifu.jp
• Psychiatry Clin. Neurosci. 2010 Feb 1;64(1):62-9.

AimsThe purpose of the present study was to examine the extent of the effects of psychopathological symptoms and cognitive function on quality of life (QOL) in patients with chronic schizophrenia.MethodsData were obtained using the Japanese Schizophrenia Quality of Life Scale (JSQLS), Positive and Negative Syndrome Scale (PANSS), Wisconsin Card-Sorting Test (WCST) Keio version, and Continuous Performance Test (CPT) for 52 schizophrenia patients.ResultsStepwise regression analysis showed that PANSS depression/anxiety factors predicted JSQLS psychosocial conditions and motivation/energy, and that WCST Categories Achieved predicted JSQLS symptoms/side-effects.ConclusionsPsychopathological symptoms and cognitive function affect subjective QOL in patients with schizophrenia. If the final goal is treatment that improves QOL in a manner that patients themselves are aware of, clinicians probably need to consider a treatment strategy that improves depression/anxiety symptom.

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