• J. Neurol. Sci. · May 2010

    Case Reports

    Differences in the time course of splenial and white matter lesions in clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).

    • Jun-ichi Takanashi, Atsushi Imamura, Fumio Hayakawa, and Hitoshi Terada.
    • Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan. jtaka@kameda.jp
    • J. Neurol. Sci. 2010 May 15;292(1-2):24-7.

    AbstractTwo patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) exhibiting lesions in the white matter and entire corpus callosum (type 2) are reported. The time course differed between the splenial lesion and other lesions in the white matter and corpus callosum other than the splenium; the latter disappeared earlier than the former. These findings strongly suggest that MERS type 2 resolves completely through MERS type 1 exhibiting an isolated splenial lesion, and MERS types 1 and 2 have the same pathophysiology. The possible prior white matter lesions in patients with MERS type 1 may explain the neurological symptoms or EEG abnormalities.Copyright 2010 Elsevier B.V. All rights reserved.

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