• European neurology · Jan 2009

    Transient disabling dyskinesias: a predictor of good outcome in subthalamic nucleus deep brain stimulation in Parkinson's disease.

    • M F Gago, M J Rosas, P Linhares, M Ayres-Basto, G Sousa, and R Vaz.
    • Department of Neurology, Faculdade de Medicina da Universidade do Porto, Hospital de São João, Porto, Portugal. miguelfgago@yahoo.com
    • Eur. Neurol. 2009 Jan 1;61(2):94-9.

    AbstractWe report 5 of 75 (6.6%) patients with Parkinson's disease (PD) submitted to subthalamic nucleus deep brain stimulation (STN-DBS) who developed transient disabling dyskinesias immediately after surgery. Dyskinesias persisted despite levodopa withdrawal, cessation or reduction of stimulation, and resolved spontaneously in a maximum period of 12 weeks without the need to change stimulation active contact. Compared to the rest of our PD patients submitted to STN-DBS, the dyskinesia group needed a lower levodopa-equivalent daily dosage (LEDD) over the time of follow-up. A microlesion in the STN, probably concealed in cerebral MRI by the electrode-related artifact, could have been involved in the etiopathology of our patients' symptoms. The presence of transient disabling dyskinesia in PD patients immediately after STN-DBS might be a predictor of good outcome as measured by a decrease in the LEDD needed.2008 S. Karger AG, Basel.

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