• Anna M Buchner, Muhammad W Shahid, Michael G Heckman, Rebecca B McNeil, Patrick Cleveland, Kanwar R Gill, Anthony Schore, Marwan Ghabril, Massimo Raimondo, Seth A Gross, and Michael B Wallace.
• Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA.
• Clin. Gastroenterol. Hepatol. 2010 Apr 1;8(4):364-70.

Background & AimsAdenoma detection rates might be improved through use of high-definition colonoscopy, which can detect subtle mucosal changes. We investigated whether the use of high-definition white-light (HDWL) colonoscopy resulted in a higher rate of adenoma detection than standard-definition white-light (SDWL) colonoscopy in a clinical practice setting.MethodsThis retrospective study included 2430 patients who underwent colonoscopies from September 2006 to December 2007; 1226 received SDWL colonoscopy and 1204 received HDWL colonoscopy. We analyzed data from consecutive screening, surveillance, and diagnostic colonoscopies, comparing adenoma and overall polyp detection between procedures. Potentially confounding variables were controlled using multivariable logistic regression analysis.ResultsThe adenoma detection rate was higher among patients who underwent HDWL compared with SDWL colonoscopies (28.8% vs 24.3%; P = .012), as was the polyp detection rate (42.2% vs 37.8%; P = .026). These findings remained after adjustments for potentially confounding variables (P = .018 and .022, respectively).ConclusionsIn a general clinical practice setting, HDWL colonoscopy resulted in a higher adenoma detection rate compared with SDWL colonoscopy. The use of SDWL colonoscopy could reduce the number of missed adenomas and the subsequent risk for colorectal cancer.Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.

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