• Ann Transl Med · Jun 2015

    Review

    Current trends in the surgical management and treatment of adult glioblastoma.

    • Richard M Young, Aria Jamshidi, Gregory Davis, and Jonathan H Sherman.
    • Department of Neurological Surgery, George Washington University Medical Center, Washington, DC 20037, USA.
    • Ann Transl Med. 2015 Jun 1;3(9):121.

    AbstractThis manuscript discusses the current surgical management of glioblastoma. This paper highlights the common pathophysiology attributes of glioblastoma, surgical options for diagnosis/treatment, current thoughts of extent of resection (EOR) of tumor, and post-operative (neo)adjuvant treatment. Glioblastoma is not a disease that can be cured with surgery alone, however safely performed maximal surgical resection is shown to significantly increase progression free and overall survival while maximizing quality of life. Upon invariable tumor recurrence, re-resection also is shown to impact survival in a select group of patients. As adjuvant therapy continues to improve survival, the role of surgical resection in the treatment of glioblastoma looks to be further defined.

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