• Pediatr Hematol Oncol · Dec 2002

    Randomized Controlled Trial Clinical Trial

    The efficacy of heparinization in prolonging patency of arterial and central venous catheters in children: a randomized double-blind trial.

    • M de Neef, H Heijboer, J B M van Woensel, and R J de Haan.
    • Department of Paediatric Intensive Care, Emma Children's Hospital, Academic Medical Center (AMC), Amsterdam, The Netherlands. m.deneef@amc.uva.nl
    • Pediatr Hematol Oncol. 2002 Dec 1;19(8):553-60.

    AbstractThis study evaluates the efficacy of heparinization in prolonging patency of arterial and central venous catheters in children. A randomized double-blind trial in a tertiary 10-bed pediatric intensive care unit was used to evaluate 300 children (age older than 4 weeks, younger than 18 years). Trial medication consisted of either NaCl 0.9% infusion or NaCl 0.9% infusion to which 1 IU of heparin per milliliter was added. The number of nonpatent arterial and central venous catheters and the duration of stay of patent arterial and central venous catheters were measured. There was a significant risk increase for nonpatency in the nonheparinized arterial catheters (relative risk [RR]: 3.54; 95% confidence interval [CI]: 1.01-12.42). No significant risk increase for nonpatency could be demonstrated for the nonheparinized central venous catheters (RR: 7.63; 95% CI: 0.40-145). The median duration of stay of the patent arterial and central venous catheters was similar for both treatment groups. These results indicate that the use of normal saline in arterial catheters is associated with an increased frequency of catheter nonpatency as compared with heparinized saline.

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