• Dig Endosc · Jan 2015

    Review

    Application of regenerative medical technology using tissue-engineered cell sheets for endoscopic submucosal dissection of esophageal neoplasms.

    • Takeshi Ohki, Masayuki Yamato, Masaho Ota, Ryo Takagi, Makoto Kondo, Nobuo Kanai, Teruo Okano, and Masakazu Yamamoto.
    • Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan; Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.
    • Dig Endosc. 2015 Jan 1;27(2):182-8.

    AbstractWe have developed a technique for endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets to an esophageal ulcer following endoscopic submucosal dissection (ESD). The epithelial cell sheets successfully prevented esophageal stricture after ESD. Key technology is that epithelial cell sheets cultured from oral mucosal tissue and attached proteins can be harvested using cell sheet technology and can be transplanted to a wound site without the use of adhesive material. This regenerative procedure can promote the epithelialization of ulceration safely and effectively. In the near future, the development of advanced endoscopic treatment of regenerative medicine shows promise.© 2014 The Authors. Digestive Endoscopy © 2014 Japan Gastroenterological Endoscopy Society.

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