Novel approaches to expanding the lung donor pool: donation

Clinics in chest medicine · Jun 2011

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Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioning.

Two novel approaches have been developed to potentially increase the availability of donor lungs for lung transplantation. In the first approach, lungs from donation after cardiac death (DCD) donors are used to increase the quantity of organ donors. In the second approach, a newly developed normothermic ex vivo lung perfusion (EVLP) technique is used as a means of reassessing the adequacy of lung function from DCD and from high-risk brain death donors prior to transplantation. This EVLP technique can also act as a platform for the delivery of novel therapies to repair injured organs ex vivo.

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- Marcelo Cypel, Jonathan C Yeung, and Shaf Keshavjee.
- Division Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, M5G 2C4, Canada.
- Clin. Chest Med. 2011 Jun 1;32(2):233-44.
AbstractTwo novel approaches have been developed to potentially increase the availability of donor lungs for lung transplantation. In the first approach, lungs from donation after cardiac death (DCD) donors are used to increase the quantity of organ donors. In the second approach, a newly developed normothermic ex vivo lung perfusion (EVLP) technique is used as a means of reassessing the adequacy of lung function from DCD and from high-risk brain death donors prior to transplantation. This EVLP technique can also act as a platform for the delivery of novel therapies to repair injured organs ex vivo.Copyright © 2011 Elsevier Inc. All rights reserved.

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Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioning.

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