• Stem Cells Transl Med · May 2014

    Review

    The decision on the "optimal" human pluripotent stem cell.

    • Margit Rosner, Katharina Schipany, and Markus Hengstschläger.
    • Medical Genetics, Medical University of Vienna, Vienna, Austria.
    • Stem Cells Transl Med. 2014 May 1;3(5):553-9.

    AbstractBecause of recent advances, the array of human pluripotent stem cells now contains embryonic stem cells, derived from "surplus" in vitro fertilization embryos or from cloned embryos; induced pluripotent stem cells; and amniotic fluid stem cells. Here, we compare these stem cell types regarding ethical and legal concerns, cultivation conditions, genomic stability, tumor developing potentials, and applicability for disease modeling and human therapy. This overview highlights that in the future appropriate methodological management must include a decision on the "optimal" stem cell to use before the specific application.

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