• M Jaeger, M Soehle, M U Schuhmann, D Winkler, and J Meixensberger.
• Department of Neurosurgery, University of Leipzig, Leipzig, Germany. jaem@medizin.uni-leipzig.de
• Acta Neurochir (Wien). 2005 Jan 1;147(1):51-6; discussion 56.

BackgroundThe purpose of this study was to investigate the relationship between continuously monitored regional cerebral blood flow (CBF) and brain tissue oxygen (PtiO2).MethodsContinuous advanced multimodal neuromonitoring including monitoring of PtiO2 (Licox, GMS) and CBF (QFlow, Hemedex) was performed in eight patients after severe subarachnoid haemorrhage (n=5) and traumatic brain injury (n=3) for an average of 9.6 days. Parameters were measured using a flexible polarographic PtiO2-probe and a thermal diffusion CBF-microprobe.FindingsRegarding the whole monitoring period in all patients, the data indicated a significant correlation between CBF and PtiO2 (r=0.36). In 72% of 400 analysed intervals of 30 minutes duration with PtiO2 changes larger than 5 mmHg, a strong correlation between CBF and PtiO2 existed (r>0.6). In 19% of intervals a still statistically significant correlation was observed (0.3ConclusionsThis study suggests a correlation between CBF and PtiO2. The level of PtiO2 seems to be predominately determined by regional CBF, since changes in PtiO2 were correlated in 90% of episodes to simultaneous changes of CBF.

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