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Randomized Controlled Trial
Effects of combined application of muscle relaxants and celecoxib administration after total knee arthroplasty (TKA) on early recovery: a randomized, double-blind, controlled study.
- Long Gong, Ji-Yuan Dong, and Zhi-Rui Li.
- Department of Orthopedics, Chinese PLA General Hospital & Chinese, PLA Postgraduate Medical School, Beijing, China.
- J Arthroplasty. 2013 Sep 1;28(8):1301-5.
AbstractThe purpose of this study was to evaluate the effectiveness of application of muscle relaxants and celecoxib in early recovery after total knee arthroplasty (TKA). One hundred and fifty patients were randomized 1:1:1 to receive either both of muscle relaxants and celecoxib or muscle relaxants alone or placebo for 2 weeks (50 patients in each group). VAS pain scores as primary efficacy, active range of motion, morphine consumption, blood loss, and postoperative complications including postoperative nausea and vomiting (PONV), extremities myasthenia and deep vein thrombosis (DVT) were determined postoperatively. Group A improved better with reduced VAS pain scores compared with another two groups. These results demonstrated that application of muscle relaxants and celecoxib into patients undergoing TKA for 2 weeks postoperative consequently improved their convalescence.Copyright © 2013. Published by Elsevier Inc.
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