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  • Crit Care · Jan 2005

    Comment Comparative Study

    Conflicting clinical trial data: a lesson from albumin.

    • Greg Martin.
    • Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, Georgia, USA. greg.martin@emory.org
    • Crit Care. 2005 Jan 1;9(6):649-50.

    AbstractAlbumin is a frequently prescribed drug in hospitalized patients, and its effect on clinical outcomes has been scrutinized in recent years. Data from meta-analyses has suggested harm related to albumin therapy in critically ill patients, and new observational data are consistent with these results. However, appropriately powered randomized, controlled trials have shown albumin to be safe in broad groups of critically ill patients. This article will discuss the reasons for differences between observational and controlled trial data, and the implications for future albumin use and clinical research.

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