• Thorac Cardiovasc Surg · Jun 2006

    Comparative Study

    Clinical impact of interstitial pneumonia following surgery for lung cancer.

    • S Takeda, H Maeda, N Sawabata, S Kitada, M Mori, S Takashima, and Y Matsubara.
    • Department of Thoracic Surgery, National Hospital Organization, Toneyama National Hospital Toyonaka, City Osaka, Japan. stakeda@toneyama.hosp.go.jp
    • Thorac Cardiovasc Surg. 2006 Jun 1;54(4):268-72.

    BackgroundOperative morbidity in patients with lung cancer associated with perioperative interstitial pneumonia (IP) has emerged as a serious problem.Patients And MethodsWe studied the clinical impact of perioperative related IP in 11 patients (IP group: 7 preoperative known, 4 acute onset) of 473 lung cancer patients who received a pulmonary resection. The IP group was compared to the remaining 462 patients (non-IP group). Demographic data, clinical presentation, and serum KL-6 levels were compared.ResultsThere were no differences in age, gender, type of surgery, and pulmonary function except for % DLco between the non-IP and IP groups. The IP group showed a higher in-hospital mortality (n=2: 18.3%) than that of the non-IP group (n=3: 0.6%) (P<0.005). Seven patients with underlying IP with high KL-6 levels showed an uneventful recovery. Two patients with postoperative onset of acute IP had a fatal course associated with elevation of serum KL-6 levels.ConclusionsPostoperative development IP is a serious complication with high mortality, and serial measurement of KL-6 levels is useful to assess the activity of IP.

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