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J Invest Allerg Clin · Jan 2006
Case ReportsCross-reactivity among amide-type local anesthetics in a case of allergy to mepivacaine.
- P González-Delgado, R Antón, V Soriano, P Zapater, and E Niveiro.
- Sección Alergia, Hospital General de Alicante, Aliccante, Spain. gonzalez_pur@gva.es
- J Invest Allerg Clin. 2006 Jan 1;16(5):311-3.
AbstractAmong the various adverse reactions to local anesthetics, IgE-mediated reactions, particularly to the more commonly used amide group, are extremely rare. We report the case of a 39-year-old man who suffered itching and generalized urticaria with facial angioedema 15 minutes after administration of mepivacaine. Skin tests revealed a strong positive reaction to mepivacaine, lidocaine, and ropivacaine, but negative reactions to bupivacaine and levobupivacaine. Furthermore, double-blind placebo-controlled subcutaneous challenge with bupivacaine and levobupivacaine was well tolerated. We conclude that an extensive allergologic study must be carried out in rare cases of true allergic reaction to amide-type local anesthetics in order to rule out cross reactivity.
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