• Am J Emerg Med · Jul 2012

    Case Reports

    Resolution of left ventricular thrombus with lepirudin after failed treatment with heparin.

    • Andrei D Margulescu and Alan G Fraser.
    • Wales Heart Research Institute, Cardiff, United Kingdom.
    • Am J Emerg Med. 2012 Jul 1;30(6):1015.e3-5.

    AbstractA 49-year-old man was admitted with high-risk left ventricular thrombosis and systemic embolization. Prompt and complete resolution of the thrombus was achieved under intravenous lepirudin administration but not under full-dose heparin treatment. Medical physicians, including emergency medicine physicians, cardiologists, cardiac surgeons, and hematologists, should become more aware of these alternative anticoagulant treatments, especially in cases when other therapeutic options (such as thrombolysis or cardiac surgery) may be associated with high morbidity or mortality.

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