• Acta pathologica japonica · Mar 1977

    Case Reports

    An autopsy case of Creutzfeldt-Jakob disease with kuru-like neuropathological changes.

    • T Hirano, H Tsuchiyama, K Kawai, and K Mori.
    • Acta Pathol. Jpn. 1977 Mar 1;27(2):231-8.

    AbstractAn autopsy case of Creutzfeldt-Jakob disease with Kuru-like neuropathological changes which revealed clinically extrapyramidal, pyramidal and psychic symptoms is presented in this report. On microscopic examination, status spongiosus, neuronal degeneration, proliferation of hypertrophic astrocytes and numerous plaques were observed in the cerebrum and cerebellum accompanied with widespread demyelinization. These plaques which suggested Kuru plaques measuring 10 to 60 micron were strongly PAS positive and had a dense central core surrounded by a halo of fine radially arranged fibrils. As for the relationship between Creutzfeldt-Jakob disease and Kuru, the significance of these morphological changes is discussed.

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