• Expert Opin Biol Ther · Feb 2008

    Review

    Oncolytic measles virus strains in the treatment of gliomas.

    • Cory Allen, Georgia Paraskevakou, Chunsheng Liu, Ianko D Iankov, Pavlos Msaouel, Paula Zollman, Rae Myers, Kah Whye Peng, Stephen J Russell, and Evanthia Galanis.
    • Mayo Clinic, Molecular Medicine Department, 200 First Street SW, Rochester, MN 55905, USA.
    • Expert Opin Biol Ther. 2008 Feb 1;8(2):213-20.

    BackgroundRecurrent gliomas have a dismal outcome despite use of multimodality treatment including surgery, radiation therapy and chemotherapy.ObjectiveIn this article the authors discuss potential applications of oncolytic measles virus strains as novel antitumor agents in the treatment of gliomas.MethodsImportant aspects of measles virus development as an anticancer therapeutic agent including engineering, retargeting and combination studies with other therapeutic modalities are discussed. The translational process that led to the first clinical trial of an engineered measles virus derivative in patients with recurrent glioblastoma multiforme is also described.Results/ConclusionsOncolytic measles virus strains hold promise as novel antitumor agents in the treatment of gliomas.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…