• Arnaud Galbois, Naïke Bigé, Claire Pichereau, Pierre-Yves Boëlle, Jean-Luc Baudel, Simon Bourcier, Eric Maury, Bertrand Guidet, and Hafid Ait-Oufella.
• AP-HP, Hôpital Saint-Antoine, Service de Réanimation Médicale, F-75012 Paris, France; Université Pierre et Marie Curie (UPMC), Univ Paris 06, Sorbonne Universités, F-75005 Paris, France; INSERM, UMR_S 938, CdR Saint-Antoine, F-75012 Paris, France. Electronic address: galbois@gmail.com.
• J. Hepatol. 2015 Mar 1;62(3):549-55.

Background & AimsSkin perfusion alterations are early and strong predictors of death in patients with septic shock. Cirrhosis is associated with systemic vasodilation and increases mortality from septic shock. We aimed at assessing whether the mottling score and tissue oxygen saturation (StO2) could be used as early predictors of death in cirrhotic patients with septic shock.MethodsThis observational study included cirrhotic patients with septic shock. Each 6 h during the first 24 h, we collected data reflecting macrocirculation (mean arterial pressure, heart rate, central venous pressure, and cardiac output) and organ perfusion (arterial lactate, urinary output, ScvO2, mottling score, thenar, and knee StO2). Data of 75 non-cirrhotic patients with previously reported septic shock were used as control.Results42 cirrhotic patients were included. Mortality at day 14 was 71%. At H6, parameters reflecting macrocirculation were not associated with mortality, whereas higher arterial lactate and mottling score were associated with death. Mottling score was the strongest predictor of mortality (sensitivity=0.63, specificity=1, OR=42.4 (2.3-785.9)). At H6, knee StO2 decreased in non-survivors and predicted death (sensitivity=0.45, specificity=1). In comparison with control, mottling kinetic was different in cirrhotic patients (delayed mottling appearance in non-survivors, earlier mottling disappearance in survivors). Knee StO2 and skin perfusion, assessed by laser-Doppler, were higher in cirrhotic patients.ConclusionsMottling score and knee StO2 at H6 were very specific predictors of death in patients with cirrhosis and septic shock. Their sensitivity was lower in cirrhotic patients due to delayed mottling appearance and higher knee StO2 related to higher skin perfusion.Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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