• Xiao Liu, Xiao-Hong Zhu, Yi Zhang, and Wei Chen.
• Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, 2021 6th St. SE, Minneapoli, MN 55455, USA.
• Brain Topogr. 2013 Jul 1;26(3):363-77.

AbstractSpatiotemporal correlations of spontaneous blood oxygenation level dependent (BOLD) signals measured in the resting brain have been found to imply many resting-state coherent networks under both awake/conscious and anesthetized/unconscious conditions. To understand the resting-state brain networks in the unconscious state, spontaneous BOLD signals from the rat sensorimotor cortex were studied across a wide range of anesthesia levels induced by isoflurane. Distinct resting-state networks covering functionally specific sub-regions of the sensorimotor system were observed under light anesthesia with 1.0% isoflurane; however, they gradually merged into a highly synchronized and spatially less-specific network under deep anesthesia with 1.8% isoflurane. The EEG power correlations recorded using three electrodes from a separate group of rats showed similar dependency on anesthesia depth, suggesting the neural origin of the change in functional connectivity specificity. The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states.

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