• Cindy Goh and Mark Agius.
• Clinical School University of Cambridge, UK.
• Psychiat Danub. 2010 Jun 1; 22 (2): 198-202.

IntroductionThe stress -vulnerability model (Zubin et al. 1977) is an extremely useful model for identifying and treating relapses of mental illness. We accept that human persons carry genetic and other predisposition to mental illness. However, the question arises as to how stress impacts on a person in order to cause mental illness to develop. Furthermore there arises the issue as to what other effects such stress has on the human body beyond the human brain. Our aim was to research and integrate the current literature in order to establish how stress impacts on the brain at the cellular level, and to establish whether there are other consequences for the human body brought about by the impact of stress on the human brain.MethodLiterature Search, using pubmed.ResultsWe have identified much literature on how stress affects biological mechanisms within the brain, and how it relates to biological vulnerabilities carried by different individuals.ConclusionWe have identified communalities in how the interplay between stress and vulnerability occurs in different disease processes.

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