• Karin Janssen van Doorn, Walter Verbrugghe, Kristien Wouters, Hilde Jansens, and Philippe G Jorens.
• Department of Nephrology-Hypertension, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
• Plos One. 2014 Jan 1;9(12):e114312.

BackgroundExploration of the impact of severe hypotension on the evolution of acute kidney injury in septic patients.Methods And ResultsWe reviewed the hemodynamic parameters of 137 adults with septic shock and proven blood stream infection in the ICU. Severe hypotension was defined as a mean arterial blood pressure (MAP) ≤65 mmHg. The influence of the duration of severe hypotension on the evolution of acute kidney injury was evaluated according to the RIFLE classification, with day 0 defined as the day of a positive blood stream infection. After bloodstream infection, the probability for a patient to be in Failure was significantly higher than before blood stream infection (OR = 1.94, p = 0.0276). Patients have a significantly higher risk of evolving to Failure if the duration of severe hypotension is longer (OR = 1.02 for each 10 minutes increase in duration of a MAP <65 mmHg, p = 0.0472). A cut-off of at least 51 minutes of severe hypotension (<65 mmHg) or at least 5.5 periods of severe hypotension within 1 day identified patients with increased risk to evolve to Failure.ConclusionsThere is a significant influence of both the duration and the number of periods of severe hypotension on the evolution to Failure. Blood stream infection has a significantly negative effect on the relationship between severe hypotension and Failure.

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