• Intensive care medicine · Dec 2001

    Case Reports

    Enoxaparin-associated severe retroperitoneal bleeding and abdominal compartment syndrome: a report of two cases.

    • A Dabney and B Bastani.
    • Division of Nephrology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St. Louis, MO 63110, USA.
    • Intensive Care Med. 2001 Dec 1;27(12):1954-7.

    ObjectiveTo describe a complication of low-molecular-weight heparin (enoxaparin) in the setting of critically ill patients.DesignCase report.SettingThe medical and surgical intensive care units of a tertiary care university teaching hospital.PatientsTwo adult patients receiving enoxaparin developed retroperitoneal hematoma and abdominal compartment syndrome. Both patients became anuric and required high-dose intravenous fluids and vasopressors to maintain blood pressure.InterventionDiscontinuation of enoxaparin, followed by exploratory laparotomy and evacuation of the hematoma.Measurements And ResultsImmediate clinical improvement following evacuation of hematoma.ConclusionsHigh-risk patients receiving low-molecular-weight heparin should be identified and closely monitored to prevent serious bleeding complications.

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