• Dario Muzevic and Bruno Splavski.
• Department of Neurosurgery, School of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, Osijek, Croatia, 31 000.
• Cochrane Db Syst Rev. 2013 Dec 16; 2013 (12): CD010193CD010193.

BackgroundSevere traumatic brain injury is a significant cause of morbidity and mortality. Treatment strategies in management of such injuries are directed to the prevention of secondary brain ischaemia, as a consequence of disturbed post-traumatic cerebral blood flow. They are usually concerned with avoiding high intracranial pressure (ICP) or adequate cerebral perfusion pressure (CPP). An alternative to this conventional treatment is the Lund concept, which emphasises a reduction in microvascular pressures.ObjectivesTo assess the role of the Lund concept versus other treatment modalities such as ICP-targeted therapy, CPP-targeted therapy or other possible treatment strategies in the management of severe traumatic brain injury.Search MethodsWe searched the Cochrane Injuries Group's Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL; Issue 10, 2013), MEDLINE (OvidSP), EMBASE (OvidSP), CINAHL Plus (EBSCO Host), ISI Web of Science (SCI-EXPANDED and CPCI-S) and trials registries. We searched the reference lists of relevant studies and published reviews found with our search. The most recent search was 5 November 2013.Selection CriteriaRandomised controlled trials (RCTs, level 1 evidence) exploring the efficacy of the Lund concept in the treatment of traumatic brain injury.Data Collection And AnalysisTwo review authors independently selected papers and made decisions about the eligibility of potentially relevant studies.Main ResultsWe found no studies that met the inclusion criteria for this review.Authors' ConclusionsThere is no evidence that the Lund concept is a preferable treatment option in the management of severe traumatic brain injury.

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