• Jing Xue, Liang Wang, Cai-Mei Chen, Jing-Yu Chen, and Zhu-Xing Sun.
• Department of Nephrology, Wuxi People's Hospital, the Affiliated Hospital of Nanjing Medical University , Jiangsu , China and.
• Ren Fail. 2014 May 1;36(4):541-5.

ObjectiveTo evaluate the association between acute kidney injury (AKI) and long-term survival in lung transplant patients.MethodsClinical data of 88 patients who underwent lung transplantation (LTx) were retrospectively analyzed at our institution from September 2002 to December 2011. Postoperative AKI was defined and divided into three groups based on creatinine criteria from the Acute Kidney Injury Net (AKIN) classification. A multivariable logistic regression model evaluated risk factors for AKI. Primary outcome was 5-year mortality. Risk adjusted multivariable COX proportional hazards regression examined the association of AKI with mortality.ResultsA total of 47 (53.40%) patients developed AKI (27 with AKIN1, 20 with AKIN2-3) in the first week after LTx. Multivariate analysis showed pre-LT (pre-lung transplant) hypertension (OR 1.37 [0.06-2.68], p=0.041) and mechanical ventilation (OR 0.05 [0.01-0.09], p=0.022) were risk factors for postoperative AKI. Five-year survival rates in the non-AKI, AKIN1, and AKIN2-3 groups were 48.8%, 37.0%, 30.0%, respectively (p=0.041). Adjusted for age, sex, type and cause of LT, hypertension and diabetes, the hazard ratio for death was 1.481 ([1.040-2.107]) for AKI.ConclusionsThe occurrence of AKI after LTx is common. Severe AKI would increase long-term mortality risk. Several variables, including pre-LT hypertension and mechanical ventilation, are associated with AKI after LTx.

24 keywords...

hide…