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Clinical biochemistry · Jul 2009
Serum procalcitonin at the time of admission to the ICU as a predictor of short-term mortality.
- Fan-Su Meng, Lei Su, You-Qing Tang, Qiang Wen, Yun-Song Liu, and Zhi-Feng Liu.
- ICU, General Hospital of Guangzhou Military Command, 111 Liu Hua Road, Yue Xiu District, Guangzhou, China.
- Clin. Biochem. 2009 Jul 1;42(10-11):1025-31.
ObjectiveThis purpose of this study was to determine if serum procalcitonin (PCT) concentration at the time of admission to the ICU is a predictor of all-cause short-term mortality.Design And MethodsThis prospective cross-sectional study was conducted over a 16-month period with 86 consecutive critically ill patients. The semi-quantitative PCT-Q test was performed and APACHE II scores and C-reactive protein (CRP) concentrations were determined within 24 h of admission.ResultsPCT-Q test value was a better predictor of all-cause short-term mortality than CRP value or APACHE II score. PCT > or = 10 ng/mL was highly and independently correlated with mortality. Use of PCT-Q > or = 10 ng/mL was superior to use of APACHE II > or = 25 or CRP > or = 10 mg/dL as a predictor of poor outcome.ConclusionsA PCT-Q value > or = 10 ng/mL obtained at the time of admission to the ICU is a strong predictor of short-term mortality.
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