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Transfusion medicine · Oct 2012
Multicenter Study Clinical TrialNational audit of the use of fibrinogen concentrate to correct hypofibrinogenaemia.
- N D Gollop, J Chilcott, A Benton, R Rayment, J Jones, and P W Collins.
- The School of Medicine, University Hospital of Wales and School of Medicine, Cardiff University Cardiff, UK.
- Transfus Med. 2012 Oct 1;22(5):350-5.
BackgroundMassive haemorrhage occurs in a variety of clinical settings resulting in consumptive and dilutional coagulopathies leading to hypofibrinogenaemia.Methods/MaterialsA prospective observational national cohort study was performed between November 2008 and June 2010 to collect safety data on the off-label use of a fibrinogen concentrate to treat acquired hypofibrinogenaemia.ResultsA prospective cohort of 63 patients with varying causes of hypofibrinogenaemia resulted from this data collection. A single infusion of fibrinogen concentrate was given in 49 (77%) of patients studied and 12 received more than one infusion. The median inter-quartile range (IQR) dose of fibrinogen infused was 49 (26-61) mg kg(-1). The median (IQR) fibrinogen level before and after infusion was 0.9 (0.6-1.3) and 1.8 (1.4-4.3) g L(-1), respectively (P < 0.001). In 31 patients (67%), bleeding stopped within 4 h and fibrinogen was reported to have contributed to this outcome by the treating clinicians. In 84% of cases the treating clinician reported that the use of fibrinogen concentrate reduced the rate of bleeding. Fibrinogen was associated with a statistically significant reduction in red blood cell transfusion (median 4 units before and 0 units after, P < 0.001) and fresh frozen plasma infusion (median 4 units before and 0 units after, P < 0.001). Three venous and one arterial non-fatal thrombotic events were recorded in the patients treated with fibrinogen.ConclusionFibrinogen concentrate can be used to correct hypofibrinogenaemia and may reduce blood product usage.© 2012 The Authors. Transfusion Medicine © 2012 British Blood Transfusion Society.
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