• The lancet oncology · Nov 2009

    Review Practice Guideline

    Management of HER2-positive breast cancer in Asia: consensus statement from the Asian Oncology Summit 2009.

    • Nan Soon Wong, Benjamin O Anderson, Kei Siong Khoo, Peng Tiam Ang, Cheng Har Yip, Yen-Shen Lu, Narind Voravud, Zhi-Ming Shao, Kathleen I Pritchard, and Asian Oncology Summit.
    • Department of Medical Oncology, National Cancer Centre, Singapore. dmowns@nccs.com.sg
    • Lancet Oncol. 2009 Nov 1;10(11):1077-85.

    AbstractPatients with breast cancer positive for human epidermal growth-factor receptor type 2 (HER2) are an important subgroup for consideration in the Asian context. Rationally designed, anti-HER2 targeted agents that can substantially improve treatment outcomes have become commercially available, but are still too costly for some groups in developed countries and for underdeveloped and developing nations. This review discusses the available evidence for optimum management of HER2-positive early and advanced breast cancer, and how this evidence can be applied to Asian countries with different levels of health-care resources and economic development--using framework provided by the Breast Health Global Initiative. We provide a brief overview of HER2 testing and discuss management of early and advanced HER2-positive breast cancer, and formulate a consensus statement for the management of breast cancer in the context of basic, limited, enhanced, and maximum health-care resource availability.

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