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- Gisélia Aparecida Freire Maia de Lima and Helena Zerlotti Wolf Grotto.
- Department of Clinical Pathology, Faculdade de Ciências Médicas, Universidade de Campinas, Campinas, São Paulo, Brazil.
- Sao Paulo Med J. 2003 Mar 5; 121 (2): 909190-1.
AbstractIron deficiency and heterozygous beta-thalassemia are important causes of hypochromic-microcytic anemia. Two laboratory parameters are suggested for the differentiation of such anemia. High-fluorescence reticulocyte counts and soluble transferrin receptor levels were determined in iron-deficiency anemia patients (n = 49) and heterozygous beta-thalassemia patients (n = 43). There was no significant difference in high-fluorescence reticulocyte and soluble transferrin receptor values between the two groups, but a correlation was observed between high-fluorescence reticulocytes and soluble transferrin receptors in iron-deficiency anemia, probably due to increased receptor synthesis as a response to decreased iron content in erythrocytes.
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