• Stereotact Funct Neurosurg · Jan 2010

    Case Reports

    A case of mania following deep brain stimulation for obsessive compulsive disorder.

    • Ihtsham U Haq, Kelly D Foote, Wayne K Goodman, Nicola Ricciuti, Herbert Ward, Atchar Sudhyadhom, Charles E Jacobson, Mustafa S Siddiqui, and Michael S Okun.
    • Department of Neurology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. ihaq@wfubmc.edu
    • Stereotact Funct Neurosurg. 2010 Jan 1;88(5):322-8.

    AbstractDeep brain stimulation (DBS) of the basal ganglia is an effective treatment for select movement disorders, including Parkinson's disease, essential tremor and dystonia. Based on these successes, DBS has been explored as an experimental treatment for medication-resistant neuropsychiatric disease. During a multiyear experience employing DBS to treat patients for obsessive compulsive disorder (OCD) we encountered several unanticipated stimulation-induced psychiatric side effects. We present a case of a young woman treated for OCD with DBS of the anterior limb of the internal capsule and nucleus accumbens region, who subsequently manifested a manic episode. We aim to discuss the case details, treatment and potential neuroanatomical underpinnings of this response.2010 S. Karger AG, Basel.

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