• Curr. Opin. Nephrol. Hypertens. · Nov 2013

    Review

    Angiogenic factors in preeclampsia: potential for diagnosis and treatment.

    • Arvind Goel and Sarosh Rana.
    • aDivision of Nephrology/Department of Medicine bMaternal Fetal Medicine/Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
    • Curr. Opin. Nephrol. Hypertens. 2013 Nov 1;22(6):643-50.

    Purpose Of ReviewThe review summarizes new observations of key roles for circulating angiogenic factors in diagnosing, managing, and treating preeclampsia.Recent FindingsAlterations in circulating angiogenic factors (soluble fms-like tyrosine kinase-1 and placental growth factor) in preeclampsia correlate with the diagnosis and adverse outcomes, particularly when the disease presents prematurely (<34 weeks). Measurement of these angiogenic biomarkers further helps differentiate preeclampsia and its complications from other disorders that present with similar clinical profiles. A ratio of soluble fms-like tyrosine kinase-1/placental growth factor greater than 85 appears ideal as the cut-off for both diagnosis and prognosis. There is also evidence that modulating these factors has therapeutic effects, suggesting a future role for angiogenic factors in treatment and prevention of preeclampsia.SummaryCirculating angiogenic biomarkers help in diagnostic and prognostic profiling of preeclampsia and may facilitate better management of these patients.

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