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- Mervyn J Eadie.
- University of Queensland, and Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia 4029, Australia. M.Eadie@uq.edu.au
- Expert Opin Drug Saf. 2008 Mar 1;7(2):195-209.
BackgroundThere is still uncertainty concerning the risk of fetal malformation associated with the intake of various individual antiepileptic drugs in pregnant women.ObjectiveTo assess the better-quality available evidence concerning the fetal hazards from exposure to antiepileptic drug monotherapy during human pregnancy.MethodExamination of the available English language literature, particularly that dealing with individual antiepileptic drugs used in monotherapy, in the larger case series with better-quality internal comparison data.ConclusionsThere is reasonable evidence that valproate is a significant teratogen during therapeutic use in women; the other older antiepileptic drugs (phenobarbitone, phenytoin, carbamazepine) probably have some teratogenic potential, but less than valproate; the situation regarding the more recently marketed antiepileptic drugs is not yet clear.
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