• Am. J. Kidney Dis. · Nov 1996

    Case Reports

    Acute massive gentamicin intoxication in a patient with end-stage renal disease.

    • C M Lu, S H James, and Y H Lien.
    • Department of Medicine, University of Arizona Health Sciences Center, Tucson 85724, USA.
    • Am. J. Kidney Dis. 1996 Nov 1;28(5):767-71.

    AbstractA 65-year-old man with end-stage renal disease on continuous ambulatory peritoneal dialysis accidentally received an acute massive overdose of gentamicin as a treatment of peritonitis. The patient developed acute vestibular dysfunction and hearing loss following the overdose. His serum gentamicin had reached the extremely toxic level of 220 microg/mL. To remove the gentamicin, the patient received hemodialysis and hemoperfusion immediately. This was followed by two more courses of hemodialysis during the following 2 days. The gentamicin level was brought down to 10 microg/mL after the third hemodialysis. Moderate and persistent high-frequency hearing loss was documented with serial audiograms. The patient made a gradual but incomplete recovery from the vestibular dysfunction. The complications of gentamicin toxicity and its management are discussed with respect to our patient.

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