• Eur. J. Med. Res. · Nov 2005

    Hyperoxic ventilation enables hemodilution beyond the critical myocardial hemoglobin concentration.

    • J Meier, G Kemming, F Meisner, A Pape, and O Habler.
    • Department of Anesthesiology, Intensive Care Medicine and Pain Control, Johann Wolfgang Goethe-University, Hospital Center, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany. Meier@em.uni-frankfurt.de
    • Eur. J. Med. Res. 2005 Nov 16;10(11):462-8.

    BackgroundWhen initiated in anemic hypoxia, hyperoxic ventilation (ventilation with pure O2, FiO2 1.0, HV) reverses hypoxia-induced ECG-changes and enables survival for several hours. The quantification of the HV-induced gain in anemia tolerance and particularly the Hb-equivalent of HV in this situation are unknown.MethodsNine anaesthetized pigs were hemodiluted under normoxia (FiO2 0.21) by exchange of whole blood for hydroxyethyl starch (HES) until predefined, ischemia associated ECG-changes occurred (timepoint Hb(crit)). From that time on all animals were ventilated with 100% O2 (FiO2 1.0). In the case of disappearance of the ECG changes with onset of HV, the animals were further hemodiluted until ECG changes reoccurred.ResultsHV initiated in anemic hypoxia (Hb 2.3 +/- 0.2 g/dl) improved ECG-readings of all animals, and allowed for a further exchange of 14 +/- 11 ml/kg blood until ECG-changes reoccurred at Hb 1.2 +/- 0.4 g/dl.ConclusionHV initiated in anemic hypoxia creates a margin of safety for myocardial tissue oxygenation and thus further increases anemia tolerance. The Hb equivalent of HV in this situation amounts to approximately 1g/dl.

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