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- Bertram Scheller, Gordon Pipa, Harry Kertscho, Patrick Lauscher, Joachim Ehrlich, Oliver Habler, Kai Zacharowski, and Jens Meier.
- Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital, Frankfurt, Germany. scheller@em.unifrankfurt.de
- Shock. 2011 Apr 1;35(4):375-81.
AbstractWe studied whether low hemoglobin concentrations during normovolemia change the myocardial electrical current (electrocardiogram) in a pig model. Normovolemic anemia was achieved by stepwise replacing blood with colloids (hydroxyethyl starch 6%). We measured the length of the PQ-, QT-, QTc, and the ST interval as well as the amplitude of the Q wave and T wave at hemoglobin concentrations of 9.5, 8.0, 5.5, 3.8, and 3.3 g·dL. Normovolemic anemia is accompanied by a gradual prolongation of the QT and QTc interval and a reduction in the amplitude of the T wave. The QRS complex is partly diminished in amplitude. Results were verified performing a time-frequency analysis on single heartbeats. During severe anemia and normovolemia, electrocardiographic changes can be detected. Further investigations are warranted to elucidate whether these changes indicate myocardial hypoxia.
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