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Neuroscience letters · Dec 2001
Maturational changes in the thermoalgesic system in humans from childhood to adulthood revealed by CO(2) laser evoked brain potentials following cutaneous heat stimuli.
- E Opsommer and L Plaghki.
- Université Catholique de Louvain, Faculty of Medicine, Avenue Emmanuel Mounier 53/READ 5375, B-1200 Brussels, Belgium. opsommer@read.ucl.ac.be
- Neurosci. Lett. 2001 Dec 28;316(3):137-40.
AbstractPossible maturational changes in the thermoalgesic system were studied by reaction times (RT) and late (Adelta-fibre) laser evoked potentials (LEPs) following CO(2) laser heat stimulation of the hand in healthy children (n=12) and young adults (n=12). In children (10+/-2 years) LEPs presented a negative-positive complex with maximum amplitude (peak-to-peak 71+/-35 microV) at the vertex and latencies of 248+/-82 and 433+/-104 ms, respectively. As compared to adults (24+/-3 years), children had a significant increased peak-to-peak amplitude (+25.7 microV; P=0.03) although no difference in latencies and topography. Median RT (710 ms) was also significantly increased (+312 ms; P<0.005) in children. A decrease in RT and late LEP amplitude from childhood to adulthood may reflect aspects of maturation in sensory processing of the thermoalgesic system.
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