• Anthony F DiMarco, Krzysztof E Kowalski, Robert T Geertman, and Dana R Hromyak.
• Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA. afd3@case.edu
• Arch Phys Med Rehabil. 2009 May 1;90(5):717-25.

ObjectiveEvaluation of the capacity of lower thoracic spinal cord stimulation (SCS) to activate the expiratory muscles and generate large airway pressures and high peak airflows characteristic of cough, in subjects with tetraplegia.DesignClinical trial.SettingInpatient hospital setting for electrode insertion; outpatient setting for measurement of respiratory pressures; home setting for application of SCS.ParticipantsSubjects (N=9; 8 men, 1 woman) with cervical spinal cord injury and weak cough.InterventionsA fully implantable electrical stimulation system was surgically placed in each subject. Partial hemilaminectomies were made to place single-disk electrodes in the epidural space at the T9, T11, and L1 spinal levels. A radiofrequency receiver was placed in a subcutaneous pocket over the anterior portion of the chest wall. Electrode wires were tunneled subcutaneously and connected to the receiver. Stimulation was applied by activating a small portable external stimulus controller box powered by a rechargeable battery to each electrode lead alone and in combination.Main Outcome MeasuresPeak airflow and airway pressure generation achieved with SCS.ResultsSupramaximal SCS resulted in high peak airflow rates and large airway pressures during stimulation at each electrode lead. Maximum peak airflow rates and airway pressures were achieved with combined stimulation of any 2 leads. At total lung capacity, mean maximum peak airflow rates and airway pressure generation were 8.6+/-1.8 (mean +/- SE) L/s and 137+/-30 cmH2O (mean +/- SE), respectively.ConclusionsLower thoracic SCS results in near maximum activation of the expiratory muscles and the generation of high peak airflow rates and positive airway pressures in the range of those observed with maximum cough efforts in healthy persons.

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