• Med Princ Pract · Jan 2012

    The frequency and significance of radiologically detected indeterminate pulmonary nodules in patients with colorectal cancer.

    • Yelda Varol, Umut Varol, Burcak Karaca, Bulent Karabulut, Canfeza Sezgin, and Ruchan Uslu.
    • Department of Chest Diseases, Izmir M Enver Senerdem Torbalı Government Hospital, Izmir, Turkey.
    • Med Princ Pract. 2012 Jan 1;21(5):457-61.

    ObjectiveTo investigate the frequency and significance of pulmonary nodules in patients with colorectal cancer (CRC).Subjects And MethodsMedical records of 1,344 patients with CRC who underwent thoracic computerized tomography scans between January 2003 and December 2009 were reviewed. Those with any distant metastatic disease or who were already known to have pulmonary malignancies were excluded. Number, size, shape and location of the nodules were evaluated. A multivariate analysis was performed to determine the predictive factors for evidence of metastases.ResultsOf the 1,344 patients, 55 (4.09%) had nodules that met the criteria of an indeterminate pulmonary nodule. The mean follow-up time was 25 ± 17.9 months and the mean time to develop pulmonary metastasis was 15.5 ± 6.4 months. The nodules of 17 (30.9%) patients showed progression at follow-up; 8 had metastasized. Multivariate analysis showed multiple indeterminate pulmonary nodules (p = 0.006) of parenchymal localization (p = 0.016) with an irregular border (p = 0.002), which is predictive of metastatic disease.ConclusionOur study has shown that multiple indeterminate pulmonary nodules with an irregular border in a parenchymal location were more likely to represent metastatic disease. However, the frequency of the occurrence of indeterminate pulmonary metastases of CRC was low.Copyright © 2012 S. Karger AG, Basel.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.