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- Seol-Ae Lee, Seong-Mo Kim, Bo Kyoung Suh, Hwa-Young Sun, Young-Un Park, Ji-Ho Hong, Cana Park, Minh Dang Nguyen, Koh-Ichi Nagata, Joo-Yeon Yoo, and Sang Ki Park.
- From the Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
- J. Biol. Chem. 2015 Mar 13;290(11):7087-96.
AbstractDysbindin and DISC1 are schizophrenia susceptibility factors playing roles in neuronal development. Here we show that the physical interaction between dysbindin and DISC1 is critical for the stability of dysbindin and for the process of neurite outgrowth. We found that DISC1 forms a complex with dysbindin and increases its stability in association with a reduction in ubiquitylation. Furthermore, knockdown of DISC1 or expression of a deletion mutant, DISC1 lacking amino acid residues 403-504 of DISC1 (DISC1(Δ403-504)), effectively decreased levels of endogenous dysbindin. Finally, the neurite outgrowth defect induced by knockdown of DISC1 was partially reversed by coexpression of dysbindin. Taken together, these results indicate that dysbindin and DISC1 form a physiologically functional complex that is essential for normal neurite outgrowth.© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
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