• Jennifer Greif Green, Katie A McLaughlin, Patricia A Berglund, Michael J Gruber, Nancy A Sampson, Alan M Zaslavsky, and Ronald C Kessler.
• Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA.
• Arch. Gen. Psychiatry. 2010 Feb 1;67(2):113-23.

ContextAlthough significant associations of childhood adversities (CAs) with adult mental disorders have been documented consistently in epidemiological surveys, these studies generally have examined only 1 CA per study. Because CAs are highly clustered, this approach results in overestimating the importance of individual CAs. Multivariate CA studies have been based on insufficiently complex models.ObjectiveTo examine the joint associations of 12 retrospectively reported CAs with the first onset of DSM-IV disorders in the National Comorbidity Survey Replication using substantively complex multivariate models.DesignCross-sectional community survey with retrospective reports of CAs and lifetime DSM-IV disorders.SettingHousehold population in the United States.ParticipantsNationally representative sample of 9282 adults.Main Outcome MeasuresLifetime prevalences of 20 DSM-IV anxiety, mood, disruptive behavior, and substance use disorders assessed using the Composite International Diagnostic Interview.ResultsThe CAs studied were highly prevalent and intercorrelated. The CAs in a maladaptive family functioning (MFF) cluster (parental mental illness, substance abuse disorder, and criminality; family violence; physical abuse; sexual abuse; and neglect) were the strongest correlates of disorder onset. The best-fitting model included terms for each type of CA, number of MFF CAs, and number of other CAs. Multiple MFF CAs had significant subadditive associations with disorder onset. Little specificity was found for particular CAs with particular disorders. Associations declined in magnitude with life course stage and number of previous lifetime disorders but increased with length of recall. Simulations suggest that CAs are associated with 44.6% of all childhood-onset disorders and with 25.9% to 32.0% of later-onset disorders.ConclusionsThe fact that associations increased with length of recall raises the possibility of recall bias inflating estimates. Even considering this, the results suggest that CAs have powerful and often subadditive associations with the onset of many types of largely primary mental disorders throughout the life course.

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