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Case Reports
Use of thrombolytic therapy to treat heparin-refractory pulmonary embolism in a menstruating patient.
- Ada Z Koch, Jawed Abubaker, V Theodore Barnett, and Lingtak-Neander Chan.
- Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Illinois 60612, USA.
- Pharmacotherapy. 2002 Jan 1;22(1):118-22.
AbstractA 26-year-old woman developed an acute pulmonary embolism at the beginning of her menstrual cycle and was admitted to the hospital. When she failed initial standard treatment with heparin, the only other therapeutic option was a thrombolytic agent such as recombinant tissue plasma activator (rt-PA). Use of these agents, however, carries a large risk of major bleeding complications and brings concern of increased menstrual blood flow and duration. A literature search of the use of thrombolytic agents in menstruating patients found only limited reports. Our patient responded well to rt-PA therapy Her hemoglobin levels remained stable, and she experienced no bleeding complications. Careful monitoring and caution are recommended when administering thrombolytic agents to menstruating patients.
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