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Am. J. Obstet. Gynecol. · Feb 1992
ReviewTreatment of uterine fibroids: current findings with gonadotropin-releasing hormone agonists.
- G D Adamson.
- Fertility Physicians of Northern California, Palo Alto.
- Am. J. Obstet. Gynecol. 1992 Feb 1;166(2):746-51.
AbstractThe gonadotropin-releasing hormone agonists have potential benefit as presurgical adjuncts in the management of uterine leiomyomas or fibroids. Uterine fibroids contain estrogen receptors and are responsive to therapeutic hormonal manipulation; gonadotropin-releasing hormone agonists are effective by inducing a state of hypoestrogenism. Clinical trials with gonadotropin-releasing hormone agonists consistently have demonstrated efficacy for decreasing both myoma size and uterine volume. The advantages of the preoperative use of gonadotropin-releasing hormone agonists include a reduction in uterine and myoma size and vascularity and potentially improved operative technique and uterine cavity integrity. Ongoing clinical trials will be needed to confirm the role of gonadotropin-releasing hormone agonists in the treatment of uterine fibroids.
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