• Expert Rev Respir Med · Feb 2012

    Review

    The clinical potential of ex vivo lung perfusion.

    • Marcelo Cypel and Shaf Keshavjee.
    • University of Toronto, ON, Canada.
    • Expert Rev Respir Med. 2012 Feb 1;6(1):27-35.

    AbstractThe number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of donor lungs. Normothermic ex vivo lung perfusion (EVLP) is a method that maintains the organ in physiologically protective conditions outside the body during preservation, and shows great promise to increase utilization of donor lungs by allowing more accurate evaluation, as well as treatment and repair, of damaged donor lungs prior to transplantation. This article will cover the rationale, technical details and results of experimental and clinical studies with EVLP. The significant potential applications of EVLP in lung transplantation, lung regeneration and oncology are discussed.

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