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Journal of neurotrauma · Nov 2007
Randomized Controlled TrialMultiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia.
- Sandra D W Buttram, Stephen R Wisniewski, Edwin K Jackson, P David Adelson, Keri Feldman, Hülya Bayir, Rachel P Berger, Robert S B Clark, and Patrick M Kochanek.
- Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA.
- J. Neurotrauma. 2007 Nov 1;24(11):1707-17.
AbstractThis study performed a comprehensive analysis of cerebrospinal fluid (CSF) cytokine levels after severe traumatic brain injury (TBI) in children using a multiplex bead array assay and to evaluate the effects of moderate hypothermia on cytokine levels. To this end, samples were collected during two prospective randomized controlled trials of therapeutic moderate hypothermia in pediatric TBI. Thirty-six children with severe TBI (Glasgow Coma Scale [GCS] score of
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