• Expert review of vaccines · Mar 2013

    Review

    Therapeutic cancer vaccines in the treatment of non-small-cell lung cancer.

    • Jean-Marc Limacher, Clémentine Spring-Giusti, Nadine Bellon, Philippe Ancian, Ronald Rooke, and Jean-Yves Bonnefoy.
    • Transgene SA, Boulevard Gonthier d'Andernach, Parc d'Innovation-CS80166, 67405 Illkirch Graffenstaden Cedex, France. limacher@transgene.fr
    • Expert Rev Vaccines. 2013 Mar 1;12(3):263-70.

    AbstractTherapeutic vaccines are different from the well-known prophylactic vaccines in that they are designed to treat patients already suffering from a disease instead of preventing the disease in healthy individuals. Several therapeutic vaccines are today in late-stage clinical development for non-small-cell lung cancer. These vaccines use different approaches including peptides, cell lines and viral vectors, and explore different settings within the pathology. Some are given in monotherapy while others are combined with the classic therapies used with non-small-cell lung cancer. This review gives a summary of the therapeutic vaccines currently in late-stage clinical development for non-small-cell lung cancer.

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