• Kidney international · Aug 2012

    Comment

    Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury.

    • Markus Bitzer, Iddo Z Ben-Dov, and Thomas Thum.
    • Kidney Int. 2012 Aug 1;82(4):375-7.

    AbstractHorizontal information transfer between cells via microparticles is a newly identified communication system. MicroRNAs regulate gene expression and are detected in microparticles. Cantaluppi et al. suggest that microparticles derived from circulating angiogenic cells--'endothelial progenitor cells' (EPCs)--harbor endothelial-protective miRNAs such as miR-126 and that delivery of EPC-derived microparticles during acute kidney ischemia-reperfusion in rats ameliorates kidney dysfunction and damage. We highlight the importance, potential future impact, and limitations of this study.

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