• J. Clin. Virol. · May 2010

    Review

    Prevention strategies for herpes zoster and post-herpetic neuralgia.

    • Myron J Levin, Anne A Gershon, Robert H Dworkin, Marc Brisson, and Lawrence Stanberry.
    • Pediatric Infectious Diseases, University of Colorado Denver, Mail Stop C227, Building 401, 1784 Racine Street, Room R09-108, Aurora, CO 80045, USA. myron.levin@ucdenver.edu
    • J. Clin. Virol. 2010 May 1;48 Suppl 1:S14-9.

    AbstractImpairment of varicella zoster virus (VZV)-specific cell-mediated immunity, including impairment due to immunosenescence, is associated with an increased risk of developing herpes zoster (HZ), whereas levels of anti-VZV antibodies do not correlate with HZ risk. This crucial role of VZV-specific cell-mediated immunity suggests that boosting these responses by vaccination will be an effective strategy for reducing the burden of HZ. Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants, anticonvulsants and analgesics.2010 Elsevier B.V. All rights reserved.

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