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Neurosci Biobehav Rev · Jul 2004
ReviewStatistical and conceptual issues in defining post-operative cognitive dysfunction.
- Matthew Lewis, Paul Maruff, and Brendan Silbert.
- Centre for Anaesthesia and Cognitive Function, Department of Anaesthesia, St Vincent's Hospital, Victoria Parade, Melbourne, Vic. 3065, Australia. m.lewis@latrobe.edu.au
- Neurosci Biobehav Rev. 2004 Jul 1;28(4):433-40.
AbstractThe occurrence of post-operative cognitive dysfunction is a distressing complication following surgery. In an effort to gain a more complete understanding of patients' cognitive recovery following surgical procedures common neuropsychological assessment tools have been adopted in a repeated measures design. It is widely regarded that this represents the most comprehensive method of determining cognitive status in this population but it has resulted in a number of statistical and conceptual difficulties in attempting to infer significant change. The current paper outlines these core difficulties and provides some potential methods to overcome these.
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