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Ugeskrift for laeger · Oct 2009
Randomized Controlled Trial[The effect of tesofensine on body weight and body composition in obese subjects--secondary publication].
- Anne-Louise Hother Nielsen, Thomas Meinert Larsen, Sten Madsbad, Leif Breum, Thomas Jon Jensen, Jens Peter Kroustrup, and Arne Astrup.
- Institut for Human Ernaering, Det Biovidenskabelige Fakultet, Københavns Universitet, DK-1958 Frederiksberg C. alhn@life.ku.dk
- Ugeskr. Laeg. 2009 Oct 5;171(41):2974-7.
AbstractResults from a phase II trial with Tesofensine for treatment of obesity are presented. In total 203 obese persons were randomised to treatment with Tesofensine 0.25, 0.5, or 1.0 mg, or placebo daily for 24 weeks. Treatment with Tesofensine resulted in a mean weight reduction of 4.5, 9.2 and 10.6% higher than that of placebo for 0.25, 0.5 and 1.0 mg, respectively. Tesofensine 0.5 mg might have the potential to produce a weight loss twice that of currently approved anti-obesity drugs. Findings of safety and efficacy of 0.5 mg Tesofensine need confirmation in phase III trials.
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