• J Arthroplasty · May 2014

    Randomized Controlled Trial

    Topical administration of tranexamic acid in primary total hip and total knee arthroplasty.

    • Joseph G Martin, Kevin B Cassatt, Katie A Kincaid-Cinnamon, Denise S Westendorf, Ann S Garton, and Jon H Lemke.
    • ORA Orthopedics PC, Bettendorf, Iowa.
    • J Arthroplasty. 2014 May 1;29(5):889-94.

    AbstractMajor blood loss is a known potential complication in total hip and total knee arthroplasty. We conducted a prospective, stratified, randomized, double-blind, placebo-controlled trial that evaluated 100 patients undergoing total knee or total hip arthroplasty to evaluate the effect on blood loss using the topical application of tranexamic acid. Participants received either 2 g of topical tranexamic acid or the equivalent volume of placebo into the joint prior to surgical closure. Tranexamic acid resulted in a lower mean maximum decline in postoperative hemoglobin levels when compared to placebo (P = 0.013). Patients in the tranexamic acid group demonstrated an improved but non-significant reduction in the units of blood transfused compared to placebo (P = 0.423). There was no clinically significant increase in complications in the tranexamic acid group, including no incidence of venous thromboembolism.© 2014.

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