• Antimicrob. Agents Chemother. · Jul 2013

    Relationship of in vitro synergy and treatment outcome with daptomycin plus rifampin in patients with invasive methicillin-resistant Staphylococcus aureus infections.

    • Warren E Rose, Andrew D Berti, Jacob B Hatch, and Dennis G Maki.
    • Pharmacy Practice Division, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA. werose@pharmacy.wisc.edu
    • Antimicrob. Agents Chemother. 2013 Jul 1;57(7):3450-2.

    AbstractWe report the findings of a study examining the relationship between in vitro daptomycin-rifampin synergy and the therapeutic outcome of 12 patients with complex deep methicillin-resistant Staphylococcus aureus (MRSA) infections treated for prolonged periods with this combination. Checkerboard synergy was found in nine cases and was 100% predictive of therapeutic success; absence of synergy was found in three cases, two of which were therapeutic failures (P = 0.045). No relationship was observed between synergy and outcome by time-kill assessment. Checkerboard synergy may predict clinical response to daptomycin plus rifampin for complex invasive MRSA infections requiring prolonged treatment.

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